Does the size or location of the unipolar low-voltage penumbra predict VT recurrence after endocardial ablation in patients with ischemic cardiomyopathy?
In patients with ischemic cardiomyopathy, VT recurrences after endocardial ablation are strongly associated with VT isthmuses located in the unipolar low-voltage penumbra and bipolar scar border, suggesting deeper intramural or epicardial substrate.
INTRODUCTION: Magnetic resonance (MR)-imaging has shown that infarct scars causing ventricular tachycardia (VT) can extend deep to and beyond bipolar low-voltage areas (LVAs) and may be a source of ablation failure. We hypothesized that the size of the unipolar LVA "penumbra" beyond the overlying bipolar scar may predict outcome of endocardial VT ablation. METHODS: Twenty consecutive patients with ischemic cardiomyopathy who underwent endocardial VT ablation were retrospectively reviewed. Bipolar (30-500 Hz) LVA defined as <1.5 mV and unipolar (0.5-500 Hz) LVA defined as <8.3 mV were reviewed on an electroanatomic mapping system. VT isthmus sites were identified from entrainment mapping, VT termination by ablation, or pace-mapping with abolition of VT inducibility by ablation. RESULTS: All bipolar LVAs (70.5 ± 20 cm(2) ) had unipolar LVAs that surrounded the bipolar LVA (147 ± 47 cm(2) ). Only 58% of the induced VTs could be mapped and ablated. During a 3-month follow-up 8/20 patients had VT recurrence. The size of the LVA penumbra was not different for those with (88 ± 47 cm(2) ) versus without (69 ± 35 cm(2) ) recurrences. However, all (8/8) of the group that recurred had isthmus/exits in the bipolar LVA border compared to only 3/12 that did not recur (100% vs. 25%; P < 0.05). Furthermore, 5/8 patients who recurred harbored VT isthmuses in the unipolar LVA penumbra than 1/12 who did not recur (63% vs. 8%; P = 0.01). CONCLUSION: In ischemic cardiomyoapthy, unipolar LVA penumbra of varying size surrounds endocardial bipolar LVA, indicating intramural/epicardial scar. Although the size of this area did not predict early recurrence after endocardial ablation, frequent recurrences after VT ablation at scar periphery suggests deeper substrate toward the infarct border.
Chopra et al. (2014) studied this question.