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June 20, 1975Science179 citations

Flavonoids as Inhibitors of Lens Aldose Reductase

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SVS.D. VarmaIMIkuo MikuniJKJ. H. Kinoshita

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Abstract

Flavonoids are effective inhibitors of lens aldose reductase. Quercetin, quercitrin, and myricitrin are significantly more potent than the previously known aldose reductase inhibitors. The inhibitory activity is of the noncompetitive type. In addition, quercitrin effectively blocks polyol accumulation in intact rat lenses incubated in medium containing high concentration of sugars.

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Cite This Study

Varma et al. (1975) studied this question.

synapsesocial.com/papers/6a204b9d80377d937a2ed1f8https://doi.org/10.1126/science.1145193
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