Key points are not available for this paper at this time.
The elevated levels of brain histidine in histidinaemic mice are detected in vivo by 1H NMR at 8.5 and 1.9 T. The concentrations determined from the in vivo spectra correlate well with subsequent analytical determinations. This technique is discussed in relation to monitoring phenylalanine in humans with phenylketonuria.
Gadian et al. (1986) studied this question.