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March 26, 2009Clinical Infectious Diseases234 citationsOpen Access

Low Sensitivity of Rapid Diagnostic Test for Influenza

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TUTimothy M. UyekiRPRamakrishna PrasadCVCharles J. Vukotich

Key Result

The QuickVue Influenza A+B Test had low sensitivity (median 27%, range 19-32%) but high specificity (median 97%, range 96-99.6%) compared with reverse-transcriptase polymerase chain reaction.

Structured PICO

Does the QuickVue Influenza A+B Test accurately diagnose influenza compared to RT-PCR in persons with influenza-like illness?

P
Population
Persons with influenza-like illness in 3 different populations
I
Intervention
QuickVue Influenza A+B Test (Quidel) on nasal swab specimens
C
Comparator
Reverse-transcriptase polymerase chain reaction (RT-PCR)
O
Outcome
Diagnostic sensitivity and specificitysurrogate

The QuickVue Influenza A+B rapid diagnostic test has low sensitivity but high specificity for detecting influenza compared to RT-PCR.

Abstract

The QuickVue Influenza A+B Test (Quidel) was used to test nasal swab specimens obtained from persons with influenza-like illness in 3 different populations. Compared with reverse-transcriptase polymerase chain reaction, the test sensitivity was low for all populations (median, 27%; range, 19%-32%), whereas the specificity was high (median, 97%; range, 96%-99.6%).

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Cite This Study

Uyeki et al. (2009) studied this question. The QuickVue Influenza A+B Test had low sensitivity (median 27%, range 19-32%) but high specificity (median 97%, range 96-99.6%) compared with reverse-transcriptase polymerase chain reaction.

synapsesocial.com/papers/6a20817847fdc8d429f42071https://doi.org/10.1086/597828
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