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May 1, 2002The Journal of PhysiologyOpen Access

Rapidly and slowly activating components of delayed rectifier K+current in guinea‐pig sino‐atrial node pacemaker cells

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Population

Isolated guinea-pig sino-atrial (SA) node pacemaker cells

Design

Preclinical

Key result

Both rapidly (IKr) and slowly (IKs) activating components of the delayed rectifier K+ current are present and play crucial roles in the spontaneous electrical activity of guinea-pig SA node cells.

Authors

HMHiroshi MatsuuraTETsuguhisa EharaWDWei‐Guang Ding

Discussion

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Overview

Should not guide human sinus node therapies; leaves open IKr/IKs roles in mammalian pacemaking.

Structured PICO

P
Population
Isolated guinea-pig sino-atrial (SA) node pacemaker cells
I
Intervention
Selective IKr inhibitor E-4031 (0.5 and 5 microM) and selective IKs inhibitor 293B (30 microM)
O
Outcome
Components and properties of the delayed rectifier K(+) current (I(K)) and their role in spontaneous electrical activitysurrogate

Both rapidly (IKr) and slowly (IKs) activating components of the delayed rectifier K+ current are present and essential for the spontaneous electrical activity of guinea-pig SA node pacemaker cells.

Cite This Study

Matsuura et al. (2002) studied this question. E-4031 and 293B was evaluated on Delayed rectifier K+ current components and spontaneous electrical activity. Both rapidly (IKr) and slowly (IKs) activating components of the delayed rectifier K+ current are present and play crucial roles in the spontaneous electrical activity of guinea-pig SA node cells.

synapsesocial.com/papers/6a208886ee274fb2963e8959https://doi.org/10.1113/jphysiol.2001.016741
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