In patients with chronic myeloid leukemia, greater intensity of type A personality traits and higher levels of type D negative affectivity were significantly associated with medication non-adherence (p=0.020 for both).
Cross-Sectional (n=140)
No
Do specific personality traits (Type A, Type D, Big Five) influence medication non-adherence in patients with chronic myeloid leukemia?
Screening for Type A and Type D personality traits (specifically negative affectivity) may help identify CML patients at higher risk for non-adherence to tyrosine kinase inhibitor therapy.
p-value: p=0.020
BACKGROUND: The introduction of BCR-ABL tyrosine kinase inhibitors (TKIs) to chronic myeloid leukemia (CML) therapy has revolutionized the treatment of this disease. Although regular TKI intake is a prerequisite for successful therapy, it has been shown that a significant proportion of patients are non-compliant. Recently there is growing evidence that personality traits may influenced the tendency for non-adherence to treatment in patients with chronic diseases. As far as we know, such a relationship in patients with CML has not been examined, yet. The aim of our study was to determine if personality traits favor non-adherence to treatment recommendations. We investigated the relationship between five-factor model personality factors (conscientiousness, neuroticism, agreeableness, extraversion, and openness) and medication non-adherence. We also checked if the patients with type A and type D personality, were at higher risk of poor medication adherence. METHODS: The following tools were used: self-constructed survey, the NEO-Five Factor Inventory, the Framingham Type A Scale, the D-Scale 14. The study included 140 CML patients treated with imatinib, dasatinib, or nilotinib. RESULTS: 39% of patients reported skipping at least one dose of medication in the month prior to follow-up visit. 51% admitted to skipping such doses from the start of their treatment to the time at which our assessment was performed. We did not find any relationship between the mean values of the analyzed factors of the Big Five (neuroticism, extraversion, openness, agreeableness, conscientiousness) and adherence. However, our analysis revealed that CML patients who admitted to missing doses of drugs during the entire course of treatment demonstrated greater intensity of type A personality traits (p = 0.020). Regarding both factors of type D personality, it was revealed that higher level of negative affectivity significantly decreased the adherence (p = 0.020). CONCLUSION: The results of our study indicate that screening for type D and A personalities may help to identify patients who are at higher risk of poor medication adherence.
Rychter et al. (2023) conducted a cross-sectional in Chronic myeloid leukaemia (n=140). Type A and Type D personality traits vs. Lower intensity of Type A and Type D traits was evaluated on Medication non-adherence (skipping doses during the entire course of treatment) (p=0.020). In patients with chronic myeloid leukemia, greater intensity of type A personality traits and higher levels of type D negative affectivity were significantly associated with medication non-adherence (p=0.020 for both).