Basic Neurochemistry: Molecular, Cellular, and Medical Aspects

Matters arising turbances, such as positive tests for rheumatoid factor, a very non-specific B-cell reaction, may also be found.However.antibodies to double stranded deoxyribonucleic acid (DNA) and extractable nuclear antigens (ENAs) are persistently negative.Histology of vessels reveals a complete absence of vasculitis with intimal thickening predominating.Although a "sero-negative" group of patients with similar manifestations undoubtedly exists, we consider it mandatory that aCl antibody estimations be undertaken in all patients with obscure cerebral disease.perhaps accompanied by vascular occlusions, such as the authors describe in their patients.Therapy with anticoagulation and/or aspirin and other antiplatelet drugs is more beneficial than steroids or immunosup- pression in these patients and may well prevent further deterioration.