February 11, 2009Angewandte Chemie International Edition231 citationsOpen Access
Phosphine‐Catalyzed Enantioselective Synthesis of Oxygen Heterocycles
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Abstract
Chiral phosphepine 1 catalyzes the transformation of an array of hydroxy-2-alkynoates into saturated oxygen heterocycles with good enantioselectivity. Phenols are also shown to participate in such phosphine-catalyzed cyclizations, including an asymmetric variant. This method provides a new approach to the enantioselective synthesis of tetrahydrofurans, tetrahydropyrans, and dihydrobenzopyrans.
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Chung et al. (2009) studied this question.