Routine stent implantation during mechanical reperfusion of acute myocardial infarction was associated with a target-vessel revascularization rate of 11.1% and angiographic restenosis in 27.5%.
Cohort (n=236)
Yes
Does primary stenting improve clinical outcomes and reduce restenosis in patients presenting with acute myocardial infarction?
Routine primary stenting during mechanical reperfusion for acute myocardial infarction is safe and associated with low rates of target-vessel revascularization and angiographic restenosis.
BACKGROUND: Restenosis has been reported in as many as 50% of patients within 6 months after PTCA in acute myocardial infarction (AMI), which necessitates repeat target-vessel revascularization (TVR) in approximately 20% of patients during this time period. Routine (primary) stent implantation after PTCA has the potential to further improve late outcomes. METHODS AND RESULTS: Primary stenting was performed as part of a prospective study in 236 consecutive patients without contraindications who presented with AMI of <12 hours' duration at 9 international centers. A mean of 1.4+/-0.7 stents were implanted per patient (97% Palmaz-Schatz) at 17.3+/-2.4 atm. During a clinical follow-up period of 7.4+/-2.6 months, death occurred in 4 patients (1.7%), reinfarction occurred in 5 patients (2.1%), and TVR was required in 26 patients (11.1%). By Cox regression analysis, small reference-vessel diameter and the number of stents implanted were the strongest determinants of TVR. Angiographic restenosis occurred in 27.5% of lesions. By multiple logistic regression analysis, the number of stents implanted and the absence of thrombus on the baseline angiogram were independent determinants of binary restenosis. CONCLUSIONS: A strategy of routine stent implantation during mechanical reperfusion of AMI is safe and is associated with favorable event-free survival and low rates of restenosis compared with primary PTCA alone.
Stone et al. (1999) conducted a cohort in Acute myocardial infarction (AMI) (n=236). Primary stenting vs. Primary PTCA alone was evaluated on Target-vessel revascularization (TVR). Routine stent implantation during mechanical reperfusion of acute myocardial infarction was associated with a target-vessel revascularization rate of 11.1% and angiographic restenosis in 27.5%.