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In the dog the net tubular reabsorption of so- dium may diminish during saline loading, inde- pendent of salt retaining hormones and even in the face of a decline in glomerular filtration rate (1-5). We have suggested that increased renal blood flow during saline loading may be one factor that contributes to the decreased tubular reabsorp- tion of sodium (4, 5), since in the saline loaded dog when renal blood flow is decreased experi- mentally the net tubular reabsorption of sodium may increase (5). Recently, reports have appeared demonstrating that the infusion of several unrelated vasodilators acetylcholine (6-8), dopa- mine (9), pyrogen (10), kallidin (11), and papa- verine (12) may increase the excretion of so- dium in association with increased renal hemody- namics. The present studies were undertaken to determine 1) the extent to which local renal vaso- dilatation may increase the excretion of sodium, 2) whether such increases in sodium excretion may be due to decreased tubular reabsorption, and 3) to what extent an effect of increased blood flow on tubular reabsorption may be operative during different degrees of saline loading.
Earley et al. (1965) studied this question.