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December 23, 1977Science445 citations

Methylphenidate in Hyperkinetic Children: Differences in Dose Effects on Learning and Social Behavior

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RSRobert L. SpragueESEsther K. Sleator

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Abstract

Methylphenidate (Ritalin) is widely prescribed for hyperkinetic children. This study showed a peak enchancement of learning in children after being given a dose of 0.3 milligram per kilogram of body weight, and a decrement in learning in those given larger doses; social behavior showed the most improvement in children given 1.0 milligram per kilogram. These results had been hypothesized from theoretical dose-response curves which indicate different target behaviors would improve at different doses.

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Cite This Study

Sprague et al. (1977) studied this question.

synapsesocial.com/papers/6a20e5d3920f77b2c049dcf2https://doi.org/10.1126/science.337493
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