Various classes of antihypertensive drugs, including beta-blockers, calcium channel antagonists, ARBs, and ACE inhibitors, may improve endothelial function and vascular inflammation in hypertension.
Do different classes of antihypertensive drugs improve endothelial function and reduce inflammation in patients with hypertension?
Certain antihypertensive drugs provide pleiotropic benefits by improving endothelial function and reducing vascular inflammation independent of blood pressure reduction.
Hypertension is characterized by structural and functional changes in blood vessels that travel with increased arterial stiffness, vascular inflammation, and endothelial dysfunction. Some antihypertensive drugs have been shown to improve endothelial function and reduce levels of inflammatory markers regardless of the effect of blood pressure lowering. Third-generation β-blockers, such as nebivolol and carvedilol, because they have additional properties, have been shown to improve endothelial function in patients with hypertension. Calcium channel antagonists, because they have antioxidant effects, may improve endothelial function and vascular inflammation.The Angiotensin Receptor Blocker (ARBs) are able to improve endothelial dysfunction and vascular inflammation in patients with hypertension and other cardiovascular diseases. Angiotensin converting enzyme (ACE) inhibitors have shown beneficial effects on endothelial function in patients with hypertension and other cardiovascular diseases, however there are few studies evaluating the effect of treatment with this class on the reduction of C-reactive protein (CRP) levels. Further studies are needed to assess whether treatment of endothelial dysfunction and vascular inflammation may improve the prognosis of patients with essential hypertension.
Silva et al. (2019) conducted a review in Hypertension. Antihypertensive drugs was evaluated. Various classes of antihypertensive drugs, including beta-blockers, calcium channel antagonists, ARBs, and ACE inhibitors, may improve endothelial function and vascular inflammation in hypertension.