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June 4, 2026Annals of Internal Medicine0 citations

P2Y12 inhibitor monotherapy vs. DAPT soon after PCI for ACS increased a composite of death or ischemic events at 30 d but not at 1 y

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MKManoj Kesarwani

Key Points

  • To investigate the effects of P2Y12 inhibitor monotherapy compared to dual antiplatelet therapy (DAPT) post-percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS).
  • Randomized trial comparing P2Y12 inhibitor monotherapy to DAPT soon after PCI.
  • Evaluated composite outcomes of death or ischemic events at 30 days and 1 year.
  • Increased composite of death or ischemic events at 30 days with monotherapy compared to DAPT.
  • No significant difference in events between groups at 1 year.

Abstract

CLINICAL IMPACT RATINGS: GIM/FP/GP: Formula: see text Cardiology: Formula: see text.

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Cite This Study

Manoj Kesarwani (2026) studied this question. P2Y12 inhibitor monotherapy compared to DAPT soon after PCI for ACS increased the composite risk of death or ischemic events at 30 days, but not at 1 year.

synapsesocial.com/papers/6a211591d499ed480b16e981https://doi.org/10.7326/annals-26-01854-jc
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1P2Y12 inhibitor monotherapy soon after PCI for ACS was not noninferior to DAPT for a composite of death or ischemic events2025
  2. 2After successful PCI for AMI and 1 mo of DAPT, P2Y12 inhibitor monotherapy was noninferior to continued DAPT for adverse outcomes2025
  3. 3Potent P2Y12 Inhibitor Monotherapy Versus Dual Antiplatelet Therapy After Percutaneous Coronary Intervention for Acute Coronary Syndromes: A Systematic Review and Meta-Analysis2026
  4. 4P2Y12 inhibitor monotherapy after short DAPT in acute coronary syndrome: a systematic review and meta-analysis2024 · 59 citations
  5. 5P2Y12 inhibitor monotherapy after complex percutaneous coronary intervention: a systematic review and meta-analysis of randomized clinical trials2023 · 6 citations