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June 4, 20260 citations

Fabrication and Evaluation of PVA-NYS-THY Nanofiber Scaffolds as Antifungal Agents Against Fluconazoleresistant Candida glabrata.

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ARAhmadian RominaLMLarypoor MohaddesehBMBayat Mansour

Key Points

  • This study aims to develop and evaluate PVA-NYS-THY nanofiber scaffolds for their antifungal properties against fluconazole-resistant Candida glabrata.
  • Characterized scaffold release kinetics and assessed antifungal efficacy using minimum inhibitory concentration (MIC) assays.
  • Measured MIC for PVA-NYS-THY, PVA-NYS, and PVA-THY formulations.
  • The MIC values were 7.81 µg/mL for PVA-NYS-THY, indicating superior antifungal activity compared to PVA-NYS at 15.62 µg/mL and PVA-THY at 62.5 µg/mL.

Abstract

Introduction: . Materials & Methods: ) gene. Scaffold release kinetics were characterized, and antifungal efficacy was assessed using minimum inhibitory concentration (MIC) assays. Results: gene expression. MIC values for PVA-NYS-THY, PVA-NYS, and PVA-THY were 7.81, 15.62, and 62.5 µg/mL, respectively, demonstrating superior antifungal activity of the PVA-NYS-THY formulation. Conclusion: , providing a novel solution to overcome current limitations in antifungal treatment.

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Cite This Study

Romina et al. (2025) studied this question.

synapsesocial.com/papers/6a2115f6d499ed480b16efb6https://doi.org/10.32598/ari.80.5.3399
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