Randomized trial examines vitamin D's effect on oxidative stress in rats, suggesting protective benefits against neurotoxicity.
Key Points
To investigate the effects of vitamin D treatment on cisplatin-induced oxidative stress in the brain.
21 Wistar Albino rats divided into three groups: control, CP, and VitD + CP.
CP group received 7 mg/kg cisplatin; VitD + CP group received 1000 IU/mL vitamin D for 7 days post-treatment.
Biochemical and histological analyses were performed on brain tissue samples.
Cisplatin increased oxidative stress and pro-inflammatory cytokines, while vitamin D treatment decreased oxidative stress levels.
Significant increases in TOS and OSI in the CP group; however, the VitD + CP group showed significant decreases in OSI.
Histological examinations revealed degenerative changes in neurons of the CP group, with reduced immunoreactivity of Nrf2, HO-1, and LC3 in the VitD + CP group.