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June 4, 2026Chemical Science0 citationsOpen Access

Distinct Adsorption Behavior and Structures of Cell-Penetrating Peptides at a Model Lipid Membrane Interface: A Heterodyne-Detected Vibrational Sum Frequency Generation Spectroscopy Study

SRSubhadip RoyMAMohammed AhmedAAAniruddha Adhikari

Key Points

  • This research aims to uncover the adsorption behavior and structural interactions of cell-penetrating peptides at lipid membrane interfaces.
  • Utilized heterodyne-detected vibrational sum frequency generation spectroscopy to analyze peptide interaction.
  • Examined distinct structures of arginine-rich cell-penetrating peptides at model lipid membranes.
  • Identified unique adsorption behaviors of cell-penetrating peptides at the lipid membrane interface.
  • Revealed specific structural changes in peptides upon interaction with the lipid environment.

Abstract

Arginine-rich cell-penetrating peptides (CPPs) are widely used as molecular delivery vectors, yet the molecular mechanism of their membrane activity and how they penetrate a cell remains unclear. Here, we investigate...

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Cite This Study

Roy et al. (2026) studied this question.

synapsesocial.com/papers/6a211852d499ed480b170e7ahttps://doi.org/10.1039/d6sc03510h
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