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October 1, 1970Circulation Research20 citationsOpen Access

Effects of Various Inotropic Interventions on the Dynamic Properties of the Contractile Elements in Heart Muscle of the Cat

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Population

Cat heart muscle

Comparison

Inotropic interventions including temperature… vs Baseline or control states for each intervention

Design

Preclinical

Authors

DBDirk L. BrutsaertWPWilliam W. ParmleyESEdmund H. Sonnenblick

Discussion

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Overview

Inotropic interventions maximize force in feline myocardium; leaves open translation to human HF management.

Structured PICO

P
Population
Cat heart muscle
I
Intervention
Inotropic interventions including temperature (29° and 37°), preload, frequency of stimulation (12/min and 24-30/min), paired stimulation (PS), calcium (2.5 mM and 7.5 mM), and isoproterenol (10^-5 M)
C
Comparator
Baseline or control states for each intervention
O
Outcome
Force-velocity-length (FVL) relations and maximum force (Po) development of the contractile elementsurrogate

Inotropic interventions such as paired stimulation, calcium, and isoproterenol significantly increase the maximum force development of the contractile element in cat heart muscle.

Cite This Study

Brutsaert et al. (1970) studied this question.

synapsesocial.com/papers/6a2147d2f69db56553c3d486https://doi.org/10.1161/01.res.27.4.513
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