Right insular stroke was associated with significantly lower SDNN and rMSSD, higher LF/HF ratio, and more complex arrhythmias compared to all other stroke patients (P<0.05).
Observational (n=103)
Does right insular ischemic damage alter heart rate variability and increase arrhythmias in patients with acute ischemic stroke?
Acute right insular ischemic damage is associated with decreased heart rate variability and more complex arrhythmias, highlighting the right insula's role in cardiac autonomic control.
p-value: p=<0.05
BACKGROUND AND PURPOSE: The insula of the right cerebral hemisphere may have a major role in cardiac autonomic control. This study was aimed at assessing the effects of acute right insular ischemic damage on heart rate variability (HRV) and arrhythmias. METHODS: Holter monitoring for 24 hours was performed in 103 consecutive patients with first-ever acute ischemic stroke. Time and frequency domain measures of HRV and arrhythmias were considered in all cases. RESULTS: Forty-nine patients (47.5%) had a right-sided infarction, whereas 54 (52.5%) had a left-sided infarction. Insular involvement was present in 33 patients with right-sided stroke (67.3%) and in 36 patients with left-sided stroke (66.6%). When compared with all other stroke patients, subjects with right-sided insular damage showed significantly lower values of the standard deviation of all normal-to-normal (SDNN) R wave to R wave (RR) intervals and of the root mean square of differences (rMSSD) of adjacent normal-to-normal RR intervals, and higher low-frequency/high-frequency ratio values (P<0.05). Right insular stroke was also associated with more complex arrhythmias than any other localization (P<0.05). Moreover, in the whole population of stroke patients, lower values of SDNN were associated with the presence of more frequent and complex arrhythmias. CONCLUSIONS: These findings further support the notion that the right insula is implicated in the autonomic control of cardiac activity and that acute right insular damage may lead to a derangement of cardiac function with potential prognostic implications.
Colivicchi et al. (2004) conducted an observational in first-ever acute ischemic stroke (n=103). Right insular ischemic damage vs. All other stroke patients was evaluated on Heart rate variability (HRV) and arrhythmias (p=<0.05). Right insular stroke was associated with significantly lower SDNN and rMSSD, higher LF/HF ratio, and more complex arrhythmias compared to all other stroke patients (P<0.05).