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sixth edition of Clinical Hematology commences with The matrix from which the blood cells are derived is the embryonic connective tissue, the mesenchyme, the sentence which opened the first edition in 1942. A few other things remain: the Wintrobe tubes in the frontispiece, the photographs of a few patients whose faces by now are as familiar as snapshots in the family album, some imperishable methods (and a few perished ones), and the unsurpassed descriptions of cellular morphology. But no accumulation of persisting details can define the great and most pervasive similarity of all the editions which is Max Wintrobe's approach to the problems of hematology. In the 25 years spanned by the six editions of Wintrobe, hematology has been the most aggressive of the medical specialties, leading the pack in such diverse areas as protein structure and function, genetics, nutrition, cytokinetics, chemotherapy of cancer, organ transplantation, and tissue freezing,
William H. Crosby (1968) studied this question.