Sildenafil decreased the mPAP/cardiac output slope and increased peak exercise right ventricular ejection fraction in post-PEA patients with normalized resting hemodynamics.
Observational (n=36)
Does sildenafil improve right ventricular function and pulmonary hemodynamics during exercise in patients with normalized resting hemodynamics after pulmonary endarterectomy?
Patients with normalized resting hemodynamics post-PEA still exhibit abnormal pulmonary vascular reserve and chronotropic incompetence during exercise, which can be partially attenuated with sildenafil.
BACKGROUND: Patients with normalized mean pulmonary artery pressure (mPAP) after pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH) do not always regain normal exercise capacity. We evaluated right ventricular function, its interaction with both pulsatile and resistive afterload, and the effect of sildenafil during exercise in these patients. METHODS AND RESULTS: Fourteen healthy controls, 15 CTEPH patients, and 7 patients with normalized resting mPAP (≤25 mm Hg) post-PEA underwent cardiopulmonary exercise testing, followed by cardiac magnetic resonance imaging with simultaneous invasive mPAP measurement during incremental supine cycling exercise. Peak oxygen consumption and peak heart rate were significantly reduced in post-PEA and CTEPH patients compared to controls. The mPAP-cardiac output slope was steeper in post-PEA patients than in controls and similar to CTEPH. Relative to controls, resting right ventricular ejection fraction was reduced in CTEPH, but not in post-PEA patients. In contrast, peak exercise right ventricular ejection fraction was reduced both in post-PEA and CTEPH patients. Exercise led to reduction of pulmonary arterial compliance in all groups. Nevertheless, resting pulmonary arterial compliance values in CTEPH and post-PEA patients were even lower than those in controls at peak exercise. In post-PEA patients, sildenafil did not affect resting hemodynamics nor right ventricular function, but decreased the mPAP/cardiac output slope and increased peak exercise right ventricular ejection fraction. CONCLUSIONS: Exercise intolerance in post-PEA patients is explained by abnormal pulmonary vascular reserve and chronotropic incompetence. The mPAP/cardiac output slope and pulmonary arterial compliance are sensitive measures demonstrating abnormal resistive and pulsatile pulmonary vascular function in post-PEA patients. These abnormalities are partially attenuated with sildenafil.
Claessen et al. (2015) conducted an observational in Chronic thromboembolic pulmonary hypertension (CTEPH) (n=36). Sildenafil vs. Baseline / Healthy controls was evaluated on Right ventricular function, mPAP-cardiac output slope, and pulmonary arterial compliance during exercise. Sildenafil decreased the mPAP/cardiac output slope and increased peak exercise right ventricular ejection fraction in post-PEA patients with normalized resting hemodynamics.