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January 3, 2018npj Digital Medicine231 citationsOpen Access

Highly flexible, wearable, and disposable cardiac biosensors for remote and ambulatory monitoring

SLStephen P. LeeGHGrace HaDWDon E. Wright

Structured PICO

Does the WiSP flexible wearable cardiac biosensor accurately measure heart rate and improve patient comfort compared to a standard Holter monitor in patients with atrial fibrillation?

P
Population
17 patients with existing clinical diagnoses of atrial fibrillation (mean age 66.9 years, 88% male, average BMI 31.5) and 7 healthy volunteers.
I
Intervention
WiSP (wearable, flexible, disposable cardiac biosensor) applied to the torso in ECG lead I or II configuration for 24 hours (AF patients) or >4 hours (healthy volunteers).
C
Comparator
Philips DigiTrak XT Holter monitor (for AF patients) and Polar H7 heart rate monitor (for healthy volunteers).
O
Outcome
Heart rate measurement accuracy and correlation compared to standard of care devices (Holter monitor or Polar H7).surrogate

The WiSP flexible wearable biosensor provides accurate continuous heart rate monitoring comparable to a standard Holter monitor while significantly improving patient comfort.

Abstract

Contemporary cardiac and heart rate monitoring devices capture physiological signals using optical and electrode-based sensors. However, these devices generally lack the form factor and mechanical flexibility necessary for use in ambulatory and home environments. Here, we report an ultrathin (~1 mm average thickness) and highly flexible wearable cardiac sensor (WiSP) designed to be minimal in cost (disposable), light weight (1.2 g), water resistant, and capable of wireless energy harvesting. Theoretical analyses of system-level bending mechanics show the advantages of WiSP's flexible electronics, soft encapsulation layers and bioadhesives, enabling intimate skin coupling. A clinical feasibility study conducted in atrial fibrillation patients demonstrates that the WiSP device effectively measures cardiac signals matching the Holter monitor, and is more comfortable. WiSP's physical attributes and performance results demonstrate its utility for monitoring cardiac signals during daily activity, exertion and sleep, with implications for home-based care.

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Cite This Study

Lee et al. (2018) studied this question.

synapsesocial.com/papers/6a21c321c614789cf207c0dehttps://doi.org/10.1038/s41746-017-0009-x
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