Why the study?
Does impedance-controlled or temperature-controlled irrigated-tip radiofrequency ablation improve safety and efficacy compared to fixed-power ablation in an ex vivo swine heart model?
Population
Freshly excised hearts from eight male pigs, perfused and superfused using oxygenated swine blood in an ex…
Comparison
Irrigated-tip radiofrequency ablation using… vs Fixed Power ablation (20 W or 30 W)
Design
Preclinical
Key result
Impedance-controlled ablation (target 10 ohm drop) created lesions comparable in depth to fixed-power ablations (6.0 vs 6.5-6.6 mm) with fewer pops and thrombus formations (2/16 vs 9-10/14).
Authors
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Impedance-controlled ablation may enhance safety in models; leaves open clinical translation pending human trials.
Does impedance-controlled or temperature-controlled irrigated-tip radiofrequency ablation improve safety and efficacy compared to fixed-power ablation in an ex vivo swine heart model?
Impedance-controlled ablation with a target 10 ohm drop provides an optimal balance of lesion depth and safety during irrigated-tip radiofrequency ablation in an ex vivo model.
Thiagalingam et al. (2007) studied Irrigated-tip catheter ablation (n=8). Impedance-controlled ablation vs. Temperature control and fixed power ablation was evaluated on Ablation lesion depth and incidence of pops and thrombus formation. Impedance-controlled ablation (target 10 ohm drop) created lesions comparable in depth to fixed-power ablations (6.0 vs 6.5-6.6 mm) with fewer pops and thrombus formations (2/16 vs 9-10/14).