Key points are not available for this paper at this time.
To cut a long story short. Single-stranded DNA aptamers that can recognize cancer cells specifically were optimized and modified. The modifications gave rise to aptamers that were much smaller in size (see scheme) and more stable in fetal bovine serum. This stability makes it possible to apply aptamers to in vivo applications, such as diagnosis and therapy. Supporting information for this article is available on the WWW under http: //www. wiley-vch. de/contents/jc₂268/2007/z600532ₛ. pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Shangguan et al. (2007) studied this question.