Female sex was not associated with significant differences in 1-year cardiovascular outcomes compared to male sex, though Magmaris scaffolds appeared more favorable than Absorb scaffolds.
Observational (n=353)
Are there sex-related differences in clinical outcomes in ACS patients treated with bioresorbable vascular scaffolds?
Both men and women have similar 1-year clinical outcomes following PCI with bioresorbable scaffolds for Acute Coronary Syndrome.
BACKGROUND: Despite the developments in percutaneous coronary interventions (PCI), women are still more likely than men to have unfavorable outcomes after PCI performed in Acute Coronary Syndrome (ACS). The mechanisms of this phenomena are not fully understood. Potential benefits of bioresorbable scaffolds (BRS) may be particularly expressed in the female population. Nevertheless, the data available currently are inconsistent and limited. This study evaluated the gender-related differences in the short-term clinical outcomes in ACS patients treated with implantation of two generations of BRS (first generation, Absorb; second generation, Magmaris). METHODS: The study was divided into two arms. To the first one, we qualified 160 patients with ACS treated with PCI who received 210 Absorb scaffolds. The second arm was composed of 193 patients with ACS who underwent PCI with Magmaris implantation. RESULTS: There were no significant sex-related differences in primary endpoints (cardiovascular-death, myocardial infarction, in-stent thrombosis) or principal secondary endpoints (of target-lesion failure, scaffold restenosis, death from any reason, other cardiovascular events) in either generation of BRS in a 1-year follow-up. CONCLUSIONS: Both genders tended to have a similar outcome in routine clinical practice following BRS implantation due to ACS. The magnesium bioresorbable scaffold (Magmaris) early outcome seemed to be more favorable in comparison to the Absorb scaffold.
Włodarczak et al. (2021) conducted an observational in Acute Coronary Syndrome (n=353). Female sex vs. Male sex was evaluated on Cardiovascular death, myocardial infarction, in-stent thrombosis. Female sex was not associated with significant differences in 1-year cardiovascular outcomes compared to male sex, though Magmaris scaffolds appeared more favorable than Absorb scaffolds.