Type 2 diabetes patients exhibited significantly decreased mean carotid wall shear stress in the middle region compared to healthy controls (0.80 vs 1.00 Pa), with further reductions observed in those with concurrent cardiovascular disease.
Cross-Sectional (n=158)
Double-blind
No
Does ultrasound vector flow imaging-derived wall shear stress differ between T2DM patients and healthy controls, and can it detect cardiovascular disease in T2DM patients?
Ultrasound vector flow imaging demonstrates that decreased mean wall shear stress at the proximal carotid bifurcation, when combined with age and BMI, is a valuable non-invasive marker for detecting cardiovascular disease in patients with type 2 diabetes.
Absolute Event Rate: 0.8% vs 1%
p-value: p=<0.001
Objectives We aimed to quantitatively analyze wall shear stress (WSS) of the common carotid artery (CCA) and elucidate the relationship between WSS and cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (T2DM) using ultrasound vector flow (V-Flow) imaging. Methods A total of 109 T2DM patients were selected as the DM group, while 49 healthy volunteers served as the control group. V-Flow examination of the bilateral CCA was conducted. The maximum wall shear stress (WSS max ) and mean wall shear stress (WSS mean ) at the bifurcation, proximal bifurcation and middle segment of the bilateral CCA were obtained. Results The DM group showed decreased WSS mean in the middle region and proximal bifurcation of the CCA compared with the control group (p 0.05). The WSS mean was further decreased in T2DM patients with CVD compared to those without CVD (middle region: 0.71 ± 0.17 Pa vs. 0.84 ± 0.24 Pa, p 0.05; proximal bifurcation: 0.62 ± 0.22 Pa vs. 0.80 ± 0.21 Pa, p 0.05). The receiver operating characteristic curve showed that a model combining with age, body mass index and WSS mean at the proximal carotid bifurcation had diagnostic value for detecting CVD in T2DM patients (area under the curve: 0.862, p 0.05). Conclusion WSS mean has potential value for evaluation of atherosclerosis, as well as in detecting the occurrence of CVD in T2DM patients. Ultrasound V-Flow imaging may be an effective tool for non-invasive evaluation of WSS in the clinic.
Li et al. (2024) conducted a cross-sectional in Type 2 diabetes mellitus (n=158). Type 2 diabetes mellitus vs. Healthy volunteers was evaluated on Mean wall shear stress (WSSmean) at the middle region of the common carotid artery (p=<0.001). Type 2 diabetes patients exhibited significantly decreased mean carotid wall shear stress in the middle region compared to healthy controls (0.80 vs 1.00 Pa), with further reductions observed in those with concurrent cardiovascular disease.