Why the study?
Does olmesartan combined with a calcium channel blocker reduce fatal and nonfatal cardiovascular events compared to olmesartan combined with a diuretic in elderly hypertensive patients?
Population
5,141 Japanese hypertensive patients aged 65 to <85 years with SBP ≥140 mmHg and/or DBP ≥90 mmHg, or SBP…
Comparison
Olmesartan combined with a dihydropyridine… vs Olmesartan combined with a low-dose diuretic
Design
RCT, randomized, open-label, blinded endpoint
Follow-up
median 3.3 years
Authors
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Similar event rates support either olmesartan-based regimen in elderly hypertension; extends comparative ARB combination data.
Does olmesartan combined with a calcium channel blocker reduce fatal and nonfatal cardiovascular events compared to olmesartan combined with a diuretic in elderly hypertensive patients?
In elderly hypertensive patients, combining olmesartan with a CCB resulted in similar cardiovascular event rates but fewer serious adverse events compared to combining olmesartan with a diuretic.
Ogihara et al. (2014) studied this question.