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June 5, 2026Virulence0 citationsOpen Access

The dual pathogenic role of IL-24 in sepsis: Coupling bacterial dissemination with inflammatory amplification as a therapeutic target

JLJinjin LuYLYuan LiaoZLZhongshuang Liu

Key Points

  • This research aims to understand the role of IL-24 in sepsis and its potential as a therapeutic target.
  • Performed experiments using recombinant IL-24 protein to study its effects on bacterial accumulation and leukocyte movement.
  • Measured sepsis-associated mortality following inhibition of IL-24 expression.
  • Recombinant IL-24 protein enhanced bacterial accumulation and leukocyte chemotaxis.
  • Inhibition of IL-24 expression significantly reduced sepsis-associated mortality.

Abstract

experiments revealed that recombinant IL-24 protein enhances the bacterial accumulation and leukocyte chemotaxis. Finally, inhibition of IL-24 expression significantly reduced sepsis-associated mortality. These findings suggest that IL-24 contributes to sepsis pathogenesis by promoting bacterial dissemination and inflammatory amplification, and identify IL-24 as a potential therapeutic target for the precise treatment of sepsis.

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Cite This Study

Lu et al. (2026) studied this question.

synapsesocial.com/papers/6a22672f763171746d545edahttps://doi.org/10.1080/21505594.2026.2673266
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