Histological and histochemical study of the effect of the alcoholic extracts of licorice and purslane, in combination with omeprazole, on experimentally induced gastric ulcers in albino rats

Here is the English version of the abstract, condensed to approximately 160 words. It maintains all scientific terminology and core findings while staying well under your 220-word limit.AbstractThis study was conducted at the College of Education, University of Al-Qadisiyah, to evaluate the therapeutic role of alcoholic extracts of Licorice and Purslane compared to Omeprazole against aspirin-induced gastric ulcers.The experiment utilized 50 male albino rats (180-200 g), divided into a negative control group and treatment groups. Gastric ulcers were induced via oral administration of aspirin (100 mg/kg). Following the 50-day experimental period, histological analysis using Hematoxylin and Eosin staining revealed severe pathological changes in the untreated ulcer group (T1), including mucosal hemorrhages, submucosal congestion, and inflammatory cell infiltration.Furthermore, PAS and Masson’s Trichrome staining showed a depleted mucus layer and sparse collagen fibers in group T1. Conversely, groups treated with plant extracts or Omeprazole (T2, T3, and T4) exhibited significant structural improvement in the gastric wall and a gradual restoration of mucosal tissue. The results suggest that Licorice and Purslane extracts possess potent regenerative properties, effectively mitigating aspirin-induced gastric damage.