This clinically focused review summarizes the epidemiology, clinical presentation, diagnostic approach, pathophysiology, and treatment of heart failure with preserved ejection fraction.
This review highlights that while HFpEF is emerging as the most common form of heart failure, there remains considerable uncertainty regarding its pathogenesis, diagnosis, and optimal treatment, with no proven therapies to improve outcomes.
Heart failure (HF) is a clinical syndrome of diverse etiologies and can be associated with preserved, reduced, or mid-range ejection fraction (EF). In the community, heart failure with preserved ejection fraction (HFpEF) is emerging as the most common form of HF. There remains considerable uncertainty regarding its pathogenesis, diagnosis, and optimal therapeutic approach. Hypotheses have been advanced to explain the underlying pathophysiology responsible for HFpEF, but to date, no specific therapy based on these hypotheses has been proven to improve outcomes in HFpEF. We provide a clinically focused review of the epidemiology, clinical presentation, diagnostic approach, pathophysiology, and treatment of HFpEF.
Gladden et al. (2018) conducted a review in Heart failure with preserved ejection fraction (HFpEF). This clinically focused review summarizes the epidemiology, clinical presentation, diagnostic approach, pathophysiology, and treatment of heart failure with preserved ejection fraction.
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