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June 28, 1985Science77 citations

Localization of the Gene Encoding the Human Interleukin-2 Receptor on Chromosome 10

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WLWarren J. LeonardTDTim DonlonRLRoger V. Lebo

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Abstract

The human interleukin-2 receptor is an inducible growth factor receptor present on the surface of activated T lymphocytes. The receptor is required for a normal T-cell immune response. High-resolution fluorescence-activated chromosome sorting and DNA spot-blot analysis with complementary DNA's for the interleukin-2 receptor indicated that the receptor gene was located on chromosome 9, 10, 11, or 12. In situ hybridization studies showed that the interleukin-2 receptor gene is on the short arm of chromosome 10, p14 → 15.

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Cite This Study

Leonard et al. (1985) studied this question.

synapsesocial.com/papers/6a22fa3ecd0d654270d26ac8https://doi.org/10.1126/science.3925551
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