Abstract Introduction Transgender and gender-diverse (TGD) individuals are subjected to unique gender minority stressors due to the systemic discrimination of their marginalised identity. These stressors, which range from external discrimination to internalised negative self-evaluation, undermine wellbeing. In contrast, resilience factors can serve as protective mechanisms. While extensively documented, research has often been confined to the role of gender minority stressors and resilience within a mental health framework. Consequently, the role of resilience has been primarily framed as a buffer for psychological distress, with its relationship to broader quality of life (QoL) domains remaining underexplored. Objective To investigate the simultaneous influence of gender minority stressors and resilience factors on the multidimensional domains of QoL in TGD individuals using a minority stress perspective. Methods A cohort of adults self-identifying as TGD was recruited from a Danish Centre for Gender Identity. Participants completed a web-based questionnaire at two time points. The WHOQOL-BREF assessed QoL across physical, psychological, social, and environmental domains, and the Gender Minority Stress and Resilience Measure (GMSRM) evaluated gender-related stressors and resilience. Data were analysed using linear mixed-effects models to examine associations with QoL, adjusting for relevant demographic covariates. Results Across all four QoL domains, resilience consistently emerged as a strong positive predictor, even after controlling for minority stress and demographic variables. In contrast, distal and proximal minority stressors, while negatively impacting QoL, demonstrated a less uniform and more domain-specific pattern of influence. Conclusions Resilience plays a robust and consistent role in supporting QoL among TGD individuals, with the potential to protect against gender minority stress across diverse life aspects. These findings emphasise the importance of focusing not only on risk but also on the mechanisms of resilience to promote well-being within TGD populations. Disclosure No
Turone et al. (2026) studied this question.