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June 6, 20260 citationsOpen Access

Koku Universe Applied to Human Heart Design: Fabrication Parameters for 3D Bioprinting (v2 — Unit-Corrected)

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YKYoshimitsu Katayama

Key Points

  • This research aims to refine the parameters for 3D bioprinting applications in human heart design.
  • Redefined contractile pressure as 16,000 Pa and myocardial stiffness as 10,000 Pa.
  • Computed dimensionless values for cardiac output and inner resolution targets.
  • Established a 5-year technology roadmap with current best practices in fabrication parameters.
  • Dimensionless minimum cardiac output calculated as 0.80 based on revised parameters.
  • Inner resolution improvement targeted at 7 um, a more ambitious goal than the current 10 um stability.

Abstract

Revised version (v2. 0) of KHDS v1. 0 with corrected unit definition for Vₘin. N is redefined as contractile pressure Pa = 16, 000 Pa (systolic LV pressure = 120 mmHg). D is redefined as myocardial stiffness Pa = 10, 000 Pa (Nagueh et al. JACC 2009; Fung 1993). V = N/D is dimensionless Pa/Pa. Vₕealthy = 16, 000/10, 000 = 1. 6 dimensionless. Vₘin = 1. 6 x (2. 5/5. 0) = 0. 80 dimensionless, corresponding to minimum cardiac output 2. 5 L/min. Inner resolution deltaᵣ = 7 um reframed as 5-year technology roadmap target (current best: 10 um stable). All other parameters unchanged: deltaᵣₒuter = 1 mm, tau = 0. 857 s.

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Cite This Study

Yoshimitsu Katayama (2026) studied this question.

synapsesocial.com/papers/6a23bbeb71a5da9775e7756ehttps://doi.org/10.5281/zenodo.20534718
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Koku Universe Framework Applied to Human Heart Design: Deriving Fabrication Parameters for 3D Bioprinting2026
  2. 2Koku Universe Framework Applied to Human Heart Design: Deriving Fabrication Parameters for 3D Bioprinting2026
  3. 3Kardio-Hikari Design Standard v1.0 (KHDS v1.0): A Proposed Capillary-Scale Design Framework for Vascularized Cardiac Tissue Engineering2026
  4. 4Optimization Framework to Identify Constitutive Law Parameters of the Human Heart2020 · 10 citations
  5. 5Defining the parameter space for construction of cardiac ventricle models2025