Introduction and Objective: Latino adults in the U.S. are disproportionately affected by Type 2 Diabetes (T2D) and report higher rates of medication non-adherence than non-Hispanic White adults. REACH-Español is a tailored text message intervention that aims to improve diabetes medication adherence among Spanish-speaking Latino adults with T2D. Here, we report participant engagement with daily text messages and assess whether engagement differs according to baseline HbA1c and health literacy level. Methods: Patients under the REACH-Español protocol (n=34) were followed for 6 months. We estimated the mean individual text-message response rate over the study period, and assessed whether the mean response rate differed according to baseline HbA1c (≥9.0% vs. 9.0%) and health literacy level (BRIEF survey score 8.0 for low literacy vs. ≥8.0 for higher literacy) using a two-sample t-test. Results: Overall, mean response rate to daily text messages was 83.6% (SD=18.7). Patients with HbA1c ≥9.0% (n =10) showed a mean response rate of 74.3% (SD=20.2), compared to 87.7% (SD=17.0) in those with HbA1c 9.0% (n=23); p=0.09. Participants with a lower health literacy score had an average response rate of 88.6% (SD=12.2), compared to those with a higher literacy level (average response rate 65.2% (SD=27.4)); p=0.07. Conclusion: Overall, there was high engagement with daily text messages in the REACH-Español text message intervention, particularly among participants with low health literacy level at baseline. Disclosure L. Bernier Rivera: None. D. Wexler: Other - Data Monitoring Committee; Ended; Novo Nordisk. Other - Data Monitoring Committee; Current; Amgen Inc. L.S. Mayberry: None. J. Seiglie: None. Funding NIH/NIDDK (K23DK135798)
RIVERA et al. (2026) studied this question.