Non-anesthesiologist-administered propofol sedation for diagnostic EUS had an 8.4% rate of sedation-related adverse events, with age and ASA class being independent predictors of risk.
Cohort (n=1,134)
Is non-anesthesiologist-administered propofol sedation safe for diagnostic EUS across different ASA risk classes?
Non-anesthesiologist-administered propofol sedation for diagnostic EUS is safe across ASA classes, though patients over 65 with ASA III status have the highest risk of predominantly minor to moderate adverse events.
Aims Endoscopic ultrasound (EUS) is a second-level endoscopic procedure with substantially greater procedural complexity than standard diagnostic endoscopy, typically requiring deeper and longer sedation. However, an optimal sedation strategy in this setting has not yet been established. This study evaluated the safety of non-anesthesiologist-administered propofol sedation (NAPS) for diagnostic EUS across ASA risk classes, focusing on sedation-related adverse events (AEs). Methods All consecutive diagnostic EUS procedures performed between January 2021 and May 2024 were included. Sedation involved balanced deep sedation using fentanyl, midazolam, and propofol administered by trained endoscopy nurses in accordance with ESGE/ESGENA guidelines. AEs were classified according to World Society of Intravenous Anesthesia definitions. Results A total of 1134 diagnostic EUS procedures performed under NAPS were analyzed. The majority were biliopancreatic (73.0%), followed by esophagogastroduodenal (21.2%) and rectal EUS (5.8%). Tissue sampling via FNB/FNA was performed in 21.3% of cases, with a diagnostic accuracy of 93%. Median dosages were 260 mg propofol, 70 μg fentanyl, and 1.6 mg midazolam, with a median procedure time of 34 minutes (range 10–132). Sedation-related AEs occurred in 95 cases (8.4%): 31 (2.7%) mild, 58 (5.1%) moderate, and 6 (0.5%) severe. All AEs were managed by endoscopy staff without the need for anesthesiologist assistance. Moderate AEs included hypotension requiring fluids (1.5%), bradycardia30 seconds (0.3%). Severe AEs included bradycardia65 years or ASA III and65 years). This model showed a significant correlation with AEs occurrence (p=0.029), with a stepwise increase in AEs rates across groups—5.6%, 9.2%, and 12.3%, respectively. Conclusions NAPS demonstrated a favorable safety profile across all ASA classes, with low rates of clinically relevant AEs. The highest AEs risk was observed in ASA III patients older than 65 years. Although these events were predominantly minor to moderate in severity, more caution could be take in this subgroup of patients. Article published online: 05 June 2026 © 2026. European Society of Gastrointestinal Endoscopy. All rights reserved. Georg Thieme Verlag KG Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
Gabbani et al. (2026) conducted a cohort in Diagnostic Endoscopic Ultrasound (EUS) (n=1,134). Non-anesthesiologist-administered propofol sedation (NAPS) was evaluated on Sedation-related adverse events (AEs). Non-anesthesiologist-administered propofol sedation for diagnostic EUS had an 8.4% rate of sedation-related adverse events, with age and ASA class being independent predictors of risk.