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November 27, 2017Chemical Science121 citationsOpen Access

Ni-catalysed regioselective 1,2-diarylation of unactivated olefins by stabilizing Heck intermediates as pyridylsilyl-coordinated transient metallacycles

STSurendra ThapaRDRoshan K. DhunganaRMRajani Thapa Magar

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Abstract

)-NiX intermediates as transient metallacycles to suppress β-hydride elimination, and facilitate transmetalation/reductive elimination. This method affords 1,2-diarylethylsilanes, which can be readily oxidized to 1,2-diarylethanols that occur as structural motifs in 3-aryl-3,4-dihydroisocoumarin and dihydrostilbenoid natural products.

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Thapa et al. (2017) studied this question.

synapsesocial.com/papers/6a28301d45b3314bfb2c7836https://doi.org/10.1039/c7sc04351a
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