Purpose To evaluate the image quality and clinical feasibility of breath-hold 3D-magnetic resonance cholangiopancreatography (MRCP) using a gradient and spin-echo (GRASE) technique with deep learning reconstruction (GRASE-DLR) versus GRASE without DLR and MRCP using a turbo spin-echo sequence with DLR (TSE-DLR) at 3 T. Methods Sixty-five consecutive patients who underwent MRCP were enrolled retrospectively. Three MRCP protocols were compared: GRASE-DLR, GRASE without DLR, and TSE-DLR. The acquisition time, image quality metrics, and diagnostic performance were assessed. Two radiologists independently performed qualitative and diagnostic assessment. Subgroup analysis was performed for patients with poor breath-hold capacity ( n = 8). Results GRASE-DLR reduced the acquisition time by 45.4% and 49.1% compared with TSE-DLR and GRASE, respectively ( p < 0.001). GRASE-DLR yielded high overall image quality (p < 0.001) and artefact reduction ( p < 0.001 vs. TSE-DLR; p < 0.05 vs. GRASE), and improved major duct visualization (p < 0.001). Diagnostically, GRASE-DLR achieved higher sensitivity for biliary disease (93.8% vs. 56.2–62.5% for TSE-DLR) and showed a trend toward higher sensitivity for pancreatic disease (87.5% vs. 55.0–72.5%). Accuracy ranged from 89.5 to 94.7% (biliary) and 84.8–87.0% (pancreatic). The area under the receiver operating characteristic curve was higher with GRASE-DLR for biliary (0.802–0.969) and pancreatic disease (0.854–0.890). Indeterminate biliary anatomical variation findings were nearly eliminated with GRASE-DLR (0–1.5% vs. 21.5–26.2% for TSE-DLR). In patients with poor breath-hold capacity, GRASE-DLR demonstrated pronounced improvements in image quality and artefact reduction. Conclusions GRASE-DLR provides favorable image quality with substantially reduced acquisition time and improved diagnostic performance, particularly in patients with poor breath-hold tolerance.
Ozaki et al. (2026) studied this question.