Why the study?
Does CCR2 expression on monocytes play a critical role in angiotensin II-induced vascular inflammation and remodeling?
Population
Wild-type mice, CCR2-deficient mice, bone marrow-transferred mice with leukocyte-selective CCR2 deficiency…
Comparison
Angiotensin II infusion; AT1 receptor blocker… vs Control mice; wild-type mice without Ang II or…
Design
Preclinical
Key result
CCR2 deficiency on monocytes blunted Angiotensin II-induced vascular inflammation and remodeling compared with control mice.
Authors
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No change to hypertension care warranted; leaves open human validation of monocyte CCR2 targeting.
Does CCR2 expression on monocytes play a critical role in angiotensin II-induced vascular inflammation and remodeling?
CCR2 expression on monocytes is critical for vascular inflammation and remodeling in angiotensin II-induced hypertension, suggesting a potential therapeutic target.
Ishibashi et al. (2004) studied Hypertension. CCR2 deficiency vs. Wild-type/control mice was evaluated on Vascular inflammation and remodeling. CCR2 deficiency on monocytes blunted Angiotensin II-induced vascular inflammation and remodeling compared with control mice.