Human Models in Mechanical Thrombectomy: A Comparative Review of Cadaveric, Perfused, and Ex Vivo Platforms (P3-4.004)

Key Points

• To evaluate the strengths and limitations of various human-based thrombectomy models for preclinical applications.
• Systematic review of static cadaveric, perfused cadaveric, and ex vivo vascular tissue models.
• Comparative analysis of the advantages and drawbacks of each thrombectomy model.
• Framework development for their role in preclinical studies.
• Identified cadaveric models offer realistic anatomical configurations but have limited flow dynamics.
• Perfused cadaveric models simulate blood flow better but may have tissue viability issues.
• Ex vivo platforms provide a balance of high fidelity and accessibility, enabling diverse applications.