Review highlights resistance mechanisms and novel strategies to improve CAR T-cell therapy efficacy in B-cell malignancies, enhancing patient survival.
Key Points
The aim is to summarize mechanisms of resistance to CAR T-cell therapy in B-cell malignancies and explore strategies to overcome these challenges.
Systematic review of studies on resistance mechanisms to CAR T-cell therapy in B-cell disorders.
Analysis of innovative therapeutic strategies like multitarget CAR design and microenvironment remodeling.
Identified tumor-intrinsic factors and CAR T-cell dysfunction as significant resistance mechanisms to CAR T-cell therapy.
Explored innovative strategies including metabolic modulation and epigenetic interventions to enhance efficacy.