In adults with long-standing Type 1 diabetes, leptin levels significantly correlated with platelet count (rho=0.235) and plateletcrit (rho=0.263, p<0.05), whereas adiponectin showed no relationships.
Cross-Sectional (n=183)
In adults with long-standing Type 1 diabetes, leptin levels are associated with platelet indices and inflammation independently of BMI, suggesting a specific adipokine-platelet interaction.
Effect estimate: rho 0.263
p-value: p=<0.05
Background: Type 1 diabetes mellitus (T1D) is associated with chronic inflammation, platelet-related alterations, and increased cardiovascular risk (CVR). The relationships between adipokines and platelet indices in long-standing T1D remain incompletely defined. Objective: To explore the relationships between adipokines (adiponectin and leptin), platelet indices, and inflammatory status in adults with long-standing T1D. Methods: This cross-sectional study included 124 adults with long-standing T1D and 59 non-diabetic controls. Platelet indices were obtained from automated blood count, and serum leptin (LEP), adiponectin (ADNC), and C-reactive protein (CRP) were measured using standardized assays. Associations were evaluated using correlation and multivariable regression analyses with adjustment for body mass index (BMI). Results: Platelet count (PLT) and plateletcrit (PCT) were higher in T1D compared with non-diabetic individuals (p = 0.003 for both), while mean platelet volume (MPV) and platelet distribution width (PDW) showed non-significant upward trends. ADNC levels were higher in T1D (p < 0.001), whereas LEP and the leptin–adiponectin ratio (LAR) did not differ between groups. In T1D, LEP correlated with PLT (rho = 0.235), PCT (rho = 0.263), and CRP (rho = 0.474), all p < 0.05. Similar associations were observed for LAR. No significant associations were found in non-diabetic controls. In multivariable analyses, PCT remained associated with LEP in T1D after adjustment for BMI, whereas in the control group, LEP was associated with BMI only. Conclusions: LEP and platelet-related indices were associated in individuals with long-standing T1D, whereas ADNC showed no such relationships. These findings suggest a distinct pattern of adipokine–platelet associations in long-standing T1D.
Чаушева et al. (2026) conducted a cross-sectional in Long-standing Type 1 Diabetes (n=183). Long-standing Type 1 diabetes vs. Non-diabetic controls was evaluated on Relationships between adipokines (adiponectin and leptin), platelet indices, and inflammatory status (rho 0.263, p=<0.05). In adults with long-standing Type 1 diabetes, leptin levels significantly correlated with platelet count (rho=0.235) and plateletcrit (rho=0.263, p<0.05), whereas adiponectin showed no relationships.