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June 17, 2026Revista Española de Cardiología (English Edition)0 citations

Cardiology care, cardiovascular comorbidities and all-cause mortality in long-term breast cancer survivors: a retrospective cohort study

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MBMarina Botello‐MarabottoMCMercè ComasDADavid Abbad-Gomez

Key Result

Use of cardiology services among long-term breast cancer survivors was associated with lower all-cause mortality, though not statistically significant (HR 0.84; 95% CI 0.67-1.05; P=.12).

Key Points

  • To describe cardiovascular comorbidities and healthcare utilization among breast cancer survivors, and their association with mortality.
  • Conducted a retrospective cohort study of 6186 breast cancer survivors diagnosed between 2000 and 2006.
  • Participants were followed up from 2012 to 2016, with data obtained from electronic health records.
  • A multivariate time-dependent Cox proportional hazards model assessed the relationship between cardiology service use and all-cause mortality.
  • 43.6% of long-term breast cancer survivors had cardiovascular disease at the beginning of follow-up.
  • 781 survivors (12.6%) died during follow-up; nonsurvivors had a greater baseline comorbidity burden (5.83 vs 1.96).
  • Use of cardiology services correlated with lower mortality (HR 0.84; 95%CI 0.67-1.05; P=0.12), though not statistically significant.

Study Design

Type

Cohort (n=6,186)

Structured PICO

Does the use of cardiology services reduce all-cause mortality in long-term breast cancer survivors?

P
Population
6,186 breast cancer survivors diagnosed between 2000 and 2006 who survived at least 5 years, followed from 2012 to 2016.
E
Exposure
Use of cardiology services
C
Comparator
No use of cardiology services
O
Outcome
All-cause mortalityhard clinical

In long-term breast cancer survivors, cardiovascular disease prevalence is high (43.6%), but cardiology service utilization is low (18.8%) and its association with reduced all-cause mortality did not reach statistical significance.

Main Result

Hazard Ratio: 0.84 (95% CI 0.67–1.05)

p-value: p=.12

Abstract

INTRODUCTION AND OBJECTIVES: Breast cancer survivors (BCS) have an elevated risk of cardiovascular disease (CVD), but standardized follow-up protocols remain limited. We aimed to describe cardiovascular comorbidities and the utilization of specialized health services, particularly cardiology services, among BCS, and to examine their association with mortality. METHODS: We conducted a retrospective cohort study of 6186 BCS diagnosed between 2000 and 2006 who survived at least 5 years after diagnosis. Participants were followed up from 2012 to 2016. Health care use and comorbidities obtained from electronic health records were analyzed. A multivariate time-dependent Cox proportional hazards model was used to assess the association between use of cardiology services and all-cause mortality. RESULTS: A total of 43.6% of long-term BCS had CVD at the beginning of follow-up. Women with CVD were older (mean age 71.8 vs 62 years; P  <  .001) and had a substantially higher comorbidity burden than those without CVD (5.83 vs 1.96; P  <  .001). During follow-up, 781 BCS (12.6%) died. Nonsurvivors were older and had a greater and more severe baseline comorbidity burden than survivors. They also had higher rates of specialist visits. Use of cardiology services was associated with lower mortality, although the association did not reach statistical significance (HR, 0.84; 95%CI, 0.67-1.05; P  =  .12). CONCLUSIONS: The prevalence of CVD among BCS was high, although only 18.8% used cardiology services. Nonsurvivors had a higher CVD burden and severity, and showed greater use of health care services.

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Cite This Study

Botello‐Marabotto et al. (2026) conducted a cohort in Breast cancer (n=6,186). Use of cardiology services vs. Non-use of cardiology services was evaluated on All-cause mortality (HR 0.84, 95% CI 0.67-1.05, p=.12). Use of cardiology services among long-term breast cancer survivors was associated with lower all-cause mortality, though not statistically significant (HR 0.84; 95% CI 0.67-1.05; P=.12).

synapsesocial.com/papers/6a3264248b0a6d04ea8e6a4fhttps://doi.org/10.1016/j.rec.2026.06.003
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