Persistent atrial fibrillation duration (>12 vs <12 months) is associated with distinctive and progressive alterations in gut microbiota and metabolic structure.
Observational
Are different durations of persistent atrial fibrillation associated with distinct alterations in gut microbiota and metabolic phenotypes?
The duration of persistent atrial fibrillation is associated with progressive alterations in gut microbiota and metabolic profiles, suggesting potential early therapeutic targets.
Atrial fibrillation was associated with a disordered gut microbiota in previous research. However, the gut microbiota signature of patients at different stages of atrial fibrillation remains largely unknown. We sought to determine whether the shift in the gut microbiota and metabolic profiles occurs early and remains stable or develops gradually during atrial fibrillation. We found that patients with persistent atrial fibrillation of 12 months shared most of the common features of gut microbiota dysbiosis. However, some distinctive and progressive alterations in the gut microbiota and metabolic structure, which may contribute to the progression of atrial fibrillation, were identified. The present study provides a comprehensive description of the dysbiotic gut microbiota and metabolic profiles in patients of short and long persistent atrial fibrillation, and our findings may help identify therapeutic strategies targeting the gut microbiota to treat atrial fibrillation at an early stage.
Zuo et al. (2019) conducted an observational in Persistent atrial fibrillation. Persistent atrial fibrillation >12 months vs. Persistent atrial fibrillation <12 months was evaluated on Gut microbiota and metabolic profiles. Persistent atrial fibrillation duration (>12 vs <12 months) is associated with distinctive and progressive alterations in gut microbiota and metabolic structure.