Paeonol and Poria cocos polysaccharide combination significantly improved cardiac function and reduced ventricular dilatation and fibrosis in rats with myocardial infarction.
Does Paeonol and Poria cocos polysaccharide combination improve cardiac function and regulate glycolipid metabolism in rats with myocardial infarction?
The combination of Paeonol and Poria cocos polysaccharide improves cardiac function and reduces adverse remodeling in a rat model of myocardial infarction through multi-targeted metabolic modulation.
Objective: To investigate the effects of Paeonol-Poria cocos polysaccharide combination on the regulation of glycolipid metabolism in rats with myocardial infarction by targeted metabolomics. Methods: A rat myocardial infarction model was established. Echocardiography, histopathology and metabolomics were used to assess the efficacy of the combination therapy. Results: The results demonstrated that Paeonol - Poria cocos polysaccharide combination led to significant improvements in cardiac function, with a reduction in ventricular dilatation and fibrosis. Metabolomics analysis identified 7 differential metabolites, significantly enriched in 5 core pathways: 1) protein digestion and absorption, 2) carbon metabolism in cancer centers, 3) arginine biosynthesis, 4) aminoacyl-tRNA biosynthesis, and 5) ABC transport pathway, which highlights the unique advantages of Traditional Chinese medicine’s multi-targeted metabolic modulation in the treatment of myocardial infarction. Conclusion: The combination of Paeonol - Poria cocos polysaccharide demonstrated significant improvements in cardiac function and inhibited ventricular dilatation and fibrosis in rats with myocardial infarction. This was achieved by synergistically regulating 5 core metabolic pathways: protein digestion and absorption, carbon metabolism in tumor centers, arginine biosynthesis, aminoacyl-tRNA biosynthesis, and ABC transporter protein.
Wang et al. (2026) studied Myocardial infarction (rat model). Paeonol and Poria cocos polysaccharide combination was evaluated on Cardiac function, ventricular dilatation, fibrosis, and metabolic pathways. Paeonol and Poria cocos polysaccharide combination significantly improved cardiac function and reduced ventricular dilatation and fibrosis in rats with myocardial infarction.