Protein S deficiency predisposes subjects to recurrent venous thromboembolism and foetal loss, although diagnostic challenges have led to conflicting reports regarding its role as a risk factor.
This review highlights the clinical implications of Protein S deficiency, particularly its role as a risk factor for venous thromboembolism and the complexities involved in its diagnosis.
Protein S (PS) is an extensively studied protein with an important function in the down-regulation of thrombin generation. Because of the presence of a pseudogene and two different forms of PS in plasma, a bound and a free form, it is one of the most difficult thrombophilias to study. A deficiency of PS predisposes subjects to (recurrent) venous thromboembolism (VTE) and foetal loss. However, the conundrum of diagnosing PS deficiency has led to conflicting reports of PS as a risk factor for VTE. In this review, we aim to present a clinical perspective of PS deficiency.
Kate et al. (2008) conducted a review in Protein S deficiency. Protein S deficiency was evaluated. Protein S deficiency predisposes subjects to recurrent venous thromboembolism and foetal loss, although diagnostic challenges have led to conflicting reports regarding its role as a risk factor.