PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
June 22, 2026Open Forum Infectious Diseases0 citationsOpen Access

Three-Year CD4/CD8 Ratio Recovery After Initiation of Dual Versus Triple Integrase Inhibitor–Based Therapy in Naïve Adults With HIV

View Full Paper
RNRoser Navarro‐SolerAGAlejandro García GarcíaJMJuan Macı́as

Key Points

  • This research aims to compare immune recovery based on the CD4/CD8 ratio following two different treatment regimens in naïve HIV adults.
  • 21,233 adults from the Spanish HIV Research Network were analyzed.
  • Propensity score-matching was used to compare two integrase inhibitor therapies, 2DR and 3DR.
  • Data were evaluated for CD4/CD8 ratio normalization at three years.
  • No detectable differences in CD4/CD8 normalization between dolutegravir-based 2DR and integrase inhibitor-based 3DR.
  • Similar immune recovery rates were observed across all measured cutoffs at three years.

Abstract

Abstract From 21,233 adults in the Spanish HIV Research Network, we used propensity score-matching to compare CD4/CD8 ratio recovery between dolutegravir-based 2DR and second-generation integrase inhibitor-based 3DR. No detectable differences in CD4/CD8 normalization were observed at three years across all cutoffs, suggesting that immune recovery does not differ between strategies.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Navarro‐Soler et al. (2026) studied this question.

synapsesocial.com/papers/6a38d129da1bad9caca30d5bhttps://doi.org/10.1093/ofid/ofag374
Ask AI
Helpful
Bookmark
Share
View Full Paper