Based on the SFL theoretical framework & G₀ fixed architecture principle derived from previous serial papers, this paper reinterprets the long-term trait changing trend of pathogenic viruses and sorts out the internal formation rule of viral attenuation effect. Traditional research mostly attributes changes in viral virulence and infectivity to adaptive evolution oriented toward environmental adaptation, while this study illustrates that continuous replication cycles and repeated host transmission will continuously accumulate irreversible genetic damage ΔGd. Such damage gradually impairs viral complete functional structure instead of generating adaptive advantages. With the growth of transmission duration T and replication generations, the deviation degree between actual viral genome and original intact G₀ framework keeps expanding, bringing about gradual decline of replication efficiency, host invasion ability and pathogenic intensity. Combined with the unified system state equation: G=G₀+ΔGd (+) -ΔGd (-) In line with the universal dissipation stability rule of complex systems, the long-term variation boundary satisfies the following constraint: ε (T) =o (1 / T) Logical deduction and practical observation both show that the long-term developing trend of most viral epidemics tends toward self-limiting functional degradation and natural recession, rather than continuous enhancement of pathogenicity. This attenuation mechanism maintains isomorphic consistency with aging consumption rules of biological cells and electronic hardware recorded in SFL-EAI serial papers, offering quantitative theoretical support for epidemic trend judgment and public health arrangement.
FOO SENG ANG (2026) studied this question.