Preoperative anaemia in patients undergoing aortic valve surgery was associated with higher unadjusted mortality (8% vs 2.8%), and lower hemoglobin independently predicted mortality (OR 1.19; P=0.007).
Cohort (n=2,698)
Does preoperative anaemia increase the risk of mortality and morbidity in patients undergoing non-emergent aortic valve surgery?
Preoperative anaemia is present in nearly a third of patients undergoing aortic valve surgery and serves as an independent predictor of early postoperative mortality and morbidity.
Odds Ratio: 1.19 (95% CI 1.04–1.34)
Absolute Event Rate: 8% vs 2.8%
p-value: p=0.007
OBJECTIVES: The impact of anaemia on patients undergoing aortic valve surgery has not been well studied. We sought to evaluate the effect of anaemia on early outcomes following aortic valve replacement (AVR). METHODS: All patients undergoing non-emergent aortic valve surgery (n = 2698) with or without other concomitant procedures between 1997 and 2010 were included. Preoperative anaemia was defined as per World Health Organization guidelines as haemoglobin (Hb) < 130 g/l in men and Hb < 120 g/l in women. Multivariable analyses were used to determine the association between preoperative anaemia and postoperative outcomes. RESULTS: The prevalence of preoperative anaemia was 32.2%. Patients with anaemia were older (71 ± 12 vs 66 ± 13 years, P < 0.001), more likely to have urgent surgery, recent MI, higher creatinine level and impaired preoperative left ventricular function. Overall unadjusted mortality was 2.8% in non-anaemic patients vs 8% in anaemic patients. Anaemic patients were more likely to require renal replacement therapy (11 vs 3%, P < 0.0001) and prolonged ventilation (24 vs 10%, P < 0.0001). Following multivariable adjustment, lower preoperative Hb was an independent predictor of mortality (odds ratio 1.19, 95% CI: 1.04-1.34, P = 0.007) and composite morbidity (odds ratio 1.36, 95% CI: 1.05-1.77, P = 0.02) after AVR. Mortality and composite morbidity were significantly higher with lower levels of preoperative Hb. CONCLUSIONS: Preoperative anaemia is a common finding in patients undergoing aortic valve surgery and is an important and potentially modifiable risk factor for postoperative morbidity and mortality.
Elmistekawy et al. (2013) conducted a cohort in Non-emergent aortic valve surgery (n=2,698). Preoperative anaemia vs. No preoperative anaemia was evaluated on Mortality (OR 1.19, 95% CI 1.04-1.34, p=0.007). Preoperative anaemia in patients undergoing aortic valve surgery was associated with higher unadjusted mortality (8% vs 2.8%), and lower hemoglobin independently predicted mortality (OR 1.19; P=0.007).