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June 29, 20260 citationsOpen Access

J-FTE7366 (Yp11.2): A Fully Accessible SNP Confirmed Across T2T, GRCh38, and GRCh37

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TVThomas James Johnson III Vincek

Key Points

  • This research aims to confirm the J-FTE7366 SNP's location and accessibility across different reference genomes.
  • Detailed mapping of SNP J-FTE7366 on T2T, GRCh38, and GRCh37 reference genomes.
  • Comparison of SNP accessibility using Big Y tests and Whole Genome Sequences.
  • Analysis of SNPs in relation to their positions on the Y chromosome.
  • J-FTE7366 confirmed at chrY:10,279,929 on T2T, chrY:9,960,846 on GRCh38, and chrY:9,798,455 on GRCh37.
  • Fully accessible to all reference assemblies without re-alignment.
  • Contrasted with T2T-exclusive SNPs that are not visible in previous assemblies.

Abstract

Every haplogroup name points to a specific mutation at a specific location on the Y chromosome. Here is exactly where J-FTE7366 sits across every reference genome. • T2T (CHM13v2.0): chrY:10,279,929, Yp11.2 • GRCh38/HG38: chrY:9,960,846 • GRCh37/HG19: chrY:9,798,455 J-FTE7366 sits on the short arm of the Y chromosome in the Yp11.2 region. It is fully accessible to all reference assemblies. Any Big Y test can reach it. Any Whole Genome Sequence can reach it. No special re-alignment is required. This stands in direct contrast to the two T2T-exclusive SNPs documented below it, J-Y637739 and J-Y637789, which sit on the long arm in the Yq11.223 ampliconic palindrome zone with no coordinate in either GRCh37 or GRCh38, and J-Y637804, sitting even further out in Yq12 at the distal tip of the long arm, also invisible to all prior assemblies. One lineage. Three regions of the Y chromosome. From the short arm to the very end of the long arm. Each one telling a different story about what current and past reference assemblies can and cannot see.

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Cite This Study

Thomas James Johnson III Vincek (2026) studied this question.

synapsesocial.com/papers/6a420b7af91bb43ea9192837https://doi.org/10.5281/zenodo.20955854
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