Population
Myosin filaments isolated from human cardiac muscle in the normal (undiseased) relaxed state
Design
Preclinical
Key result
A 28-Å resolution 3D reconstruction of human cardiac muscle myosin filaments revealed axial and azimuthal head perturbations and defined atomic arrangements within the three crown levels.
Authors
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Hypothesis-generating for myosin-based cardiomyopathy mechanisms; leaves open clinical translation pending functional validation.
The 3D reconstruction of the human cardiac muscle myosin filament provides structural insights that will aid in understanding the effects of mutations associated with human cardiomyopathies.
AL-Khayat et al. (2012) studied Normal (undiseased) human cardiac muscle. A 28-Å resolution 3D reconstruction of human cardiac muscle myosin filaments revealed axial and azimuthal head perturbations and defined atomic arrangements within the three crown levels.