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July 5, 2026British Journal of Pharmacology0 citationsOpen Access

Peripheral Mechanisms and Targets In Neuropathic Pain

Peripheral targets for neuropathic pain

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Authors

AAAmirhossein AfsharipourCCCosmin I. CiotuFRFelix J. Resch

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Overview

Review highlights molecular targets for neuropathic pain and ongoing clinical trials for treatment options.

Key Points

  • The review aims to identify and discuss molecular targets related to neuropathic pain, especially those in peripheral mechanisms.
  • Analyzed molecular targets associated with neuropathic pain using the IUPHAR/BPS database.
  • Classified targets into 'large', 'rising', and 'novel' based on their literature occurrence.
  • Discussed the top 15 targets in each category and their clinical trial status.
  • Ion channels are more prevalent in established targets compared to novel ones.
  • The analysis identified promising novel targets with preclinical evidence for neuropathic pain.
  • Ongoing clinical trials indicate potential new drugs and mechanisms for established and novel targets.

Cite This Study

Afsharipour et al. (2026) studied this question.

synapsesocial.com/papers/6a49f5d7f5d1d45b288007cahttps://doi.org/10.1111/bph.70553
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